Home News "Once Human: Top PvE & PvP Builds, Weapons, Gear"

"Once Human: Top PvE & PvP Builds, Weapons, Gear"

Author : Sarah Apr 13,2025

In Once Human, the gear and weapons you choose are pivotal to your success in combat, whether you're facing off against corrupted beasts in PvE zones or raiding player settlements in PvP. A well-synergized build can mean the difference between thriving and having to restart.

This comprehensive guide explores four of the most potent builds in the latest version of Once Human. We delve into details about weapons, gear modifications, synergy effects, and offer playstyle tips. From builds that excel in area-of-effect (AoE) damage for clearing zones to those that specialize in damage-over-time (DoT) and critical burst damage, each build has been tested for effectiveness in both solo and team scenarios.

If you're just starting out, be sure to read our Beginner’s Guide for Once Human for a thorough introduction to the game!

blog-image-OH_BUG_ENG_1

Final Tips for Optimizing Your Build

  • Sync weapon effects and mods: Select gear that amplifies your weapon’s elemental or status effects for maximum impact.
  • Keep upgrading: Higher rarity and enhancement levels significantly increase your build's effectiveness—avoid using outdated gear.
  • Craft backup loadouts: A secondary build focused on different elements can help you adapt to various mutant types or counter strategies in PvP.

Each build in Once Human is tailored for specific scenarios, be it boss fights, wave clearing, or quick PvP takedowns. Experiment with different loadouts, fine-tune your gear mods, and switch builds based on the mission type or the enemy's resistances.

For the ultimate gaming experience—featuring lag-free aiming, multi-instance farming, and swift inventory management—consider playing Once Human on BlueStacks. Enjoy full control support and ultra-smooth frames per second to optimize your gameplay.

Latest Articles More
  • EA Sports FC Mobile teams up with La Liga

    Historic Partnership Brings Spanish Football to MobileEA Sports FC Mobile is bringing the excitement of Spanish football to players' fingertips through a special collaboration with La Liga. This three-stage in-game event will showcase the league's ri

    Feb 09,2026
  • Cyberpunk 2 Begins Development at CD Projekt

    Cyberpunk 2077's sequel, currently referred to as Cyberpunk 2, has officially entered pre-production, as confirmed by developer CD Projekt.The studio announced this milestone in its latest financial results, revealing that the Phantom Liberty expansi

    Feb 09,2026
  • Crab Invasion: iOS Launch, Android Pre-Register Now

    King of Crabs: Invasion has launched on iOS, with Android pre-registrations still open.It blends the beloved King of Crabs cast with a fresh puzzle RTS style.Win battles by swarming foes or deploying elite troops at critical moments.The King of Crabs

    Feb 08,2026
  • NetEase Launches Sea of Remnants Adventure

    NetEase's upcoming title Sea of Remnants has gamers buzzing with anticipationThe pirate-themed game features a distinctive musical styleWhile details remain scarce, the teaser has sparked widespread speculationNetEase's reputation has undergone a rem

    Feb 08,2026
  • Honkai Star Rail Launches Repose Chapter Update

    Version 3.2 of Honkai: Star Rail introduces a wealth of new content for players.Two new five-star characters, Castorice (Remembrance) and Anaxa (Erudition), have arrived.Special events and activities are planned to celebrate the game's second anniver

    Jan 23,2026
  • Palworld's Switch Port Halted by Technical Hurdles, Not Pokemon

    While not completely dismissing the possibility of a Switch version, Palworld CEO Takuro Mizobe has highlighted the technical challenges involved in bringing the game to the Nintendo platform.Related VideoIs a Switch Version of Palworld Feasible?Tech

    Jan 23,2026